The Innate Immune Response to Infection

Book Description

This book demonstrates that nutrients play a direct role as co-factors and regulators of the immune system. The book also shows that modulating the immune response with nutrients can provide a fundamental approach to preventive medicine.;Containing nearly 2300 bibliographic citations as well as illustrative figures, tables, and micrographs, this book is designed to be of interest to clinical immunologists, immunology and vitamin researchers, nutrition specialists, paediatricians, neonatologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.

Gold and Silver Staining: Techniques in Molecular Morphology (Advances in Pathology, Microscopy, & Molecular Morphology)

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Gold and Silver Staining: Techniques in Molecular Morphology (Advances in Pathology, Microscopy, & Molecular Morphology)

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

Biotechnology | Biological Sciences | Science | Subjects | Books

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ASIN: 0849313929

Book Description

Immunogold silver staining is one of the most sensitive techniques available for visualizing the location of antibodies and nucleotide probes that have been bounded to specific antigens or to nucleotide sequences. As gold and silver staining continues to advance research in molecular morphology, this book presents the information you need to know about the various staining methods, their useful applications, and the advantages and drawbacks of each process. Gold and Silver Staining: Techniques in Molecular Morphology provides a timely description of approaches, methods, protocols, and applications. The contributors cover the latest developments and a wide range of applications from highly sensitive detection of antigens to single copy detection of DNA and RNA. Some of the authors are "living legends" in the field and bring their expertise and experience to this fine collaboration. Written in one consistent style, each chapter includes a concise, but comprehensive introduction, step-by-step protocols with technical hints, and a discussion of results and critical steps. What differentiates this book from all others like it, is the status of the editors, who have worked on this technique from its inception and have produced innumerable publications on the topic. The other distinguishing feature is that all of the contributors are amongst the absolute foremost leaders from the United States and Europe. Gold and Silver Staining: Techniques in Molecular Morphology presents a complete overview and detailed descriptions of this technique that allows the visualization of molecules that have never been localized before and with hitherto unknown sensitivity. Not only does this book provide an excellent review of this field, but it also serves as a lab manual for those who want to carry out this technique in their laboratory and clinical work. Armed with this information, advances in this powerful field of research will ensue.

Paul Erlich's Receptor Immunology: The Magnificent Obsession

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Paul Erlich's Receptor Immunology: The Magnificent Obsession
Arthur M. Silverstein
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

Immunology | Basic Science | Medicine | Subjects | Books

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ASIN: 0126437653

Book Description

This book describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field.

the selectionist theory of antibody formation
kinetics of primary and secondary antibody response
quantitative methods of measurement of antigens and antibody
demonstration of passive transfer of immunity from mother to foetus

The Leucocyte Antigen: Facts Book (Factsbook)

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The Leucocyte Antigen: Facts Book (Factsbook)
A. Neil Barclay , Marion H. Brown , S. K. Alex Law , Andrew J. McKnight , Michael G. Tomlinson , and P. Anton van der Merwe
Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback

Biochemistry | Biological Sciences | Science | Subjects | Books

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ASIN: 0120781859

Book Description

A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook was hugely successful. The new Second Edition has been completely revised, updated, and expanded by 65% to include new findings and up-to-date key references. The introductory chapters have also been updated, especially in terms of nomenclature, the role of the World Wide Web, and new structural data. The Leucocyte Antigen FactsBook, Second Edition contains more than 200 entries, with approximately 70 new entries, on all the molecules specifically expressed in the surface of cells of the haematopoietic system, including all characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors. This FactsBook will be of enormous value to immunologists, cell biologists, biochemists, and endocrinologists.

Key Features
* Completely up-to-date
* Revised and expanded to include over 70 new entries
* More than 200 entries in total, plus additional introductory material
* New structural data
* New nomenclature for CD and related molecules covered

Immune and Inflammatory Responses in the Nervous System (The Molecular and Cellular Neurobiology Series (Bios Scientific Publishers).)

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Immune and Inflammatory Responses in the Nervous System (The Molecular and Cellular Neurobiology Series (Bios Scientific Publishers).)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0198509804

Book Description

This new edition covers recent advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms involved to intervene in, and arrest, neurodegenerative disease processes. Immune and Inflammatory Responses in the Nervous System covers developmental aspects of immune/inflammatory responses in the CNS, basic aspects of glial function, as well as inflammatory mediators, their mechanisms of action, clinical importance and sites of infection. There is also coverage of the major diseases of the CNS, including stroke, brain injury, multiple sclerosis and Alzheimer's disease. Throughout, the focus is on the underlying basic neuroscience, clinical relevance and the potential for therapeutic interventions. This will be an invaluable aid to understanding and improving the diagnosis of neuroimmune diseases and determining therapeutic measures. The contributors are all leading experts in the field and the content will be of interest to neuroscientists, neurologists, neuropathologists, neurosurgeons and immunologists.

Dendritic Cell Protocols (Methods in Molecular Medicine)

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Essential reading for those working in the DC field

Dendritic Cell Protocols (Methods in Molecular Medicine)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

Research | Education | Science | Subjects | Books

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ASIN: 0896035840

Book Description

Stephen P Robinson, MD, PhD, and Andrew Stagg, PhD, have brought together a wide range of time-proven methods for studying these dendritic cells. Many of these readily reproducible techniques deal with the problem of obtaining sufficient dendritic cells for analysis, whether by isolation from a wide vareity of tissues, or from various progenitor cell populations. Other methods describe in step-by-step fashion the techniques commonly used for analyzing aspects of dendritic cells, ranging from cell migration to antigen uptake and T cell stimulation. In addition, a few techniques explore the practical challenges involved in using dendritic cells in a clinical setting to develop novel immunotherapeueutics.

Customer Reviews:

Essential reading for those working in the DC field.......2006-06-14

This book is an invaluable reference for all manner of work in dendritic cells. The detailed protocols within are true time-savers, and have saved me many headaches and wasted hours looking up and cross-referring the same information in the literature. Although published a few years ago, the information is still completely germane in 2006 and the protocols are extremely well-written and helpful.

The Immune Response: Basic and Clinical Principles

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The Immune Response: Basic and Clinical Principles
Tak W. Mak , and Mary Saunders
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

Immunology | Basic Science | Medicine | Subjects | Books

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The Autoimmune Diseases, Fourth Edition
Biology of Cancer
The Regulatory Genome: Gene Regulatory Networks In Development And Evolution
Intuitive Biostatistics
The Immune System

ASIN: 0120884518
Release Date: 2005-09-27

Book Description

The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences.

* Current and thorough 30 chapter reference reviewed by luminaries in the field
* Unique single voice' ensures consistency of definitions and concepts
* Comprehensive and elegant illustrations bring key concepts to life
* Provides historical context to allow fuller understanding of key issues
* Introductory chapters 1-4 serve as an Immunology Primer' before topics are discussed in more detail
* Includes a CD-ROM containing all the figures and plates appearing in the book

Virus dynamics: Mathematical principles of immunology and virology

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A good introduction

Virus dynamics: Mathematical principles of immunology and virology
Martin A. Nowak , and Robert May
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

AIDS | Disorders & Diseases | Health, Mind & Body | Subjects | Books

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Similar Items:

Mathematical Epidemiology of Infectious Diseases: Model Building, Analysis and Interpretation (Wiley Series in Mathematical & Computational Biology)
Evolutionary Dynamics: Exploring the Equations of Life
Infectious Diseases of Humans: Dynamics and Control (Oxford Science Publications)
Epidemic Modelling: An Introduction (Cambridge Studies in Mathematical Biology)
Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management (Cambridge Studies in Adaptive Dynamics)

ASIN: 0198504179

Book Description

We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study.

Customer Reviews:

A good introduction.......2001-04-09

This book is best described as the application of nonlinear ordinary differential equations to immunology and virology. It's primary emphasis is on understanding the time development of viral infections, drug treatments, and viral resistance of the HIV and hepatitis-B viruses.

The authors do a good job of describing the relevant equations needed to model virus dynamics. The book would be a good beginning for mathematicians interested in going into the field of mathematical immunology. And, even though it should be classified as a monograph, rather than a textbook, since there are no problem sets, students of mathematical immunology should find this book a useful introduction to the subject. In addition, the authors give a large list of references at the end of each chapter for further reading.

Mathematicians who need a background in the biology of the HIV virus will find a good discussion in Chapter 2 of the book. The authors give an historical summary of the origins and treatment of the virus in this chapter. This sets the stage for the mathematical modeling of virus dynamics in Chapter 3, where the authors define the basic reproductive ratio and write down a system of three coupled nonlinear ordinary differential equations as the basic equations of virus dynamics. They remark, though without justification, that an analytical solution of the time development is not possible, and so they use approximation schemes to solve the equations. The equations are a phenomenological representation of virus dynamics, and no attempt is made to relate the rate constants to the underlying microscopic properties/structures/processes of viruses. They do however discuss the empirical data associated with studies of SIV infections, and show convincingly there is a correlation between the initial growth of the virus and its value at equilibrium. They caution the reader that the basic model does not give the true reproductive ratio, and show how to correct for this by introducing time delays.

The efficacy of drug therapy is treated from both a mathematical and experimental viewpoint in the next chapter. This is a very enlightening discussion from the standpoint of the validation of the virus models.

The authors switch gears in the next chapter and talk about the dynamics of the Hepatitus B virus. Again, they do a good job of introducing the reader to the experimental evidence for the models of this virus.

In chapter 6, they bring in the contribution of the immune system to the basic equations. They assume that the reader is familiar with the concept of CTL responsiveness. The resulting equations are somewhat more complicated, and the authors show how the ubiquitous Lotka-Volterra equations arise with the virus being the prey, and the immune system the predator. No detailed phase space analysis is done however to study any of the equations in this chapter, which would have been useful to the reader.

The chapter on quasispecies is the most interesting one in the book, as the authors not only give a rudimentary definition of quasispecies, but they also give an indication of their complexity. Disappointingly, they mention the idea of mutation rates and their connection with chaos and self-organized criticality, but do not elaborate on this at all.

The Bonhoeffer's laws of anti-viral treatment are discussed in the next chapter and the authors show how to derive them using the basic model. The emergence of resistance during drug treatment is modeled by parameters which reflect the replication rates of the virus, but these parameters are again not connected with any underlying microscopic properties of the virus.

Some interesting dynamical behavior occurs for the case of multiple epitopes where the existence of quasiperiodic oscillations is shown to occur. They authors refer to this as "unpredictable" but they do not define this term in the book. The existence of quasiperiodic orbits in a dynamical system does not by itself make the system "unpredictable" or random of some sort.

This book is a very addition to the literature, and most importantly, it emphasizes the role of validating mathematical models experimentally, which takes on even greater importance given the medical ramifications of the topics in this book.

Positive Options for Living with Lupus: Self-Help and Treatment (Positive Options)
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Wonderful info - looks at other symptoms not just ANA test

Positive Options for Living with Lupus: Self-Help and Treatment (Positive Options)
Philippa Pigache
Manufacturer: Hunter House
ProductGroup: Book
Binding: Paperback

Lupus | Disorders & Diseases | Health, Mind & Body | Subjects | Books
Rheumatic Diseases | Disorders & Diseases | Health, Mind & Body | Subjects | Books
Immune Systems | Disorders & Diseases | Health, Mind & Body | Subjects | Books
General | Health, Mind & Body | Subjects | Books
Similar Items:

The First Year--Lupus: An Essential Guide for the Newly Diagnosed

Living with Lupus (Overcoming Common Problems)

The Lupus Book: A Guide for Patients and Their Families

Lupus Handbook for Women: Up-to-Date Information on Understanding and Managing the Disease Which Affects

New Hope for People with Lupus: Your Friendly, Authoritive Guide to the Latest in Traditional and Complementary Solutions

ASIN: 0897934873

Book Description

The effects of lupus — a difficult-to-diagnose condition in which the immune system attacks the body — can be mild or life threatening. Therapy and awareness of lupus have improved greatly in recent years, and this book contains the latest information about the disease, its diagnosis, and its cures. The book covers different types of lupus; self-care and when to call the doctor; lupus and pregnancy; self-help measures, including rest, diet, and exercise; complementary remedies; dealing with flares; and coping with work and money difficulties.

Customer Reviews:

Wonderful info - looks at other symptoms not just ANA test.......2007-03-22

What a wonderful and insightful book. Having gone through several Rheumies and the whole denial thing, this book would have saved time and heartache. Philippa Pigache has included various ways of pinpointing the signs of SLE including the St. Thomas' Criteria. She also touches on various treatments including pharmaceutical as well as alternatives. Most importantly, she doesn't forget the mental well being of a person suffering from SLE!

I highly recommend this book for anyone that think they may have a form of Lupus to those that have been diagnosed. She also touches on Sjogren's, FMS, MCTD, Avascular Necrosis, Libman-Sacks and DIL.

It isn't "Systemic Lupus Erythematosus" by Geroge C. Tsokos, Caroline Gordon and Josef S. Smolen nor is it "Dubois' Lupus Erythematosus" but it does cover much valuable information that doesn't read like a medical tome.

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